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===Antidepressant=== Major depressive disorders include many subtypes, most of which are treated through the use of antidepressant medications. Depression can come from many sources, most of which are centered on changes in body chemistry. Neuroscience findings in the 1990s and 2000s indicated long-term depression is caused chiefly by neurochemical imbalance, a premise upheld by subsequent research. Consequently, most front-line antidepressants work by reducing the reuptake of key neurotransmitters, boosting their levels in the brain. Current front-line antidepressants reduce reuptake of serotonin and, less frequently, norepinephrine. In addition to an antidepressant regimen, general recommendations include psychological therapy. Ongoing research has shown possible links that would indicate changes to diet and activity could also have positive effects in combating major depressive disorder, but such findings have not yet been scientifically verified. Depression is a serious medical condition. If someone believes they may be depressed - or if they know someone who seems depressed - medical advice and attention should be sought as soon as possible. While treatment efficacy is still highly variable, it is far worse for depression to go untreated. Learn more on [[wikipedia:Antidepressant|Wikipedia]] or [http://apps.who.int/classifications/icd10/browse/2016/en#/F32 ICD sections F32 and F33]
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